Langerhans Cell Sarcoma
What is a Sarcoma
What is a Sarcoma
Sarcomas are a group of cancers arising in the connective tissues, including fat, muscle, cartilage and bone.
Sarcomas account for less than 3% of all cancers. Almost 90% of sarcomas occur in adults but affect a younger population than most cancers. Sarcomas comprise 20% of cancers in children and up to 10% in young adults ...
information sourced from www.australiansarcomagroup.org
Langerhans Cell Sarcoma is a very rare subtype of Sarcoma. So rare that I would be surprised if there were more than 50 cases EVER documented, but then its hard to know as records are hard to obtain.
It is not to be confused with Langerhans Cell Histiocytosis , which is another condition that occurs mainly in children, of which there more cases worldwide.
Treatments are experimental as there is little known about it. I wanted to start this website as a way to connect with others that have been diagnosed in order to combine knowledge between our medical teams . Whilst researching for known cases ( of which I have only found a handful) overseas, I realized that there is a need for us to connect to give us the best chance .
KNOWLEDGE IS POWER.
THE MORE YOU KNOW ABOUT YOUR CONDITION,
THE BETTER YOU CAN DEAL WITH IT.
Langerhans Cell Sarcoma ( translated )
Langerhans σάρκωμα κελί
sarcoma de cèl lules de Langerhans
sarcome à cellules de Langerhans
Langerhansovih stanica sarkom
Langerhans Cel sarcoom
sarcoma di cellule di Langerhans
клеток Лангерганса саркома
Langerhans cell sarkom
sarcoma de células de Langerhans
Langerhans celle sarkom
Langerhanske celler sarkom
langerhans klefi sarkmein
Why I have started this webpage
My son, Daniel was diagnosed with this very rare Cancer late 2009. He was 18 at the time. He is doing really well as of September 2017 and there is no sign of tumour re occurrence. My reason for this website is to find other cases worldwide ( to date I have only found a handful) . We live in Sydney, Australia. Daniel was the only known case in this country, but we now know of another case in Adelaide.
Definitions- from internet sites
langerhans cell sarcoma
Rare malignant neoplasm of dendritic LANGERHANS CELLS exhibiting atypical cytology, frequent mitoses, and aggressive clinical behavior. They can be distinguished from other histiocytic and dendritic proliferations by immunohistochemical and ultrastructure studies. Cytologically benign proliferations of Langerhans cells are called LANGERHANS CELL HISTIOCYTOSIS.
Langerhans cell sarcoma is exceedingly rare. It has been reported in both adults and children. Multisystem involvement includes lymph nodes, liver, spleen, lung, and bone. Histology (Fig. 16-35) shows large cells with malignant features including hyperchromatic nuclei and prominent nucleoli. There may be nuclear grooves similar to those found in Langerhans cell histiocytosis, and there is a high mitotic rate. Birbeck granules are present on electron microscopy. Immunohistologic staining shows S-100 and focal CD1a positivity and, in some cases, positivity for CD68, CD45, and lysozyme.